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Water-soluble B vitamin

Pantothenic acid, the coenzyme A builder

Pantothenic acid, also called vitamin B5, is a water-soluble B vitamin the body uses to make coenzyme A, which it needs to build and break down fats1.

VitaminsTracked in mgDaily target3 sources · checked 2026-09-27

How much you need

A halved avocado with its stone leaning against a whole avocado
Photo: John Vid on Unsplash (Unsplash License)
01 What it does

What pantothenic acid does for you.

Food into energy

Helps turn the food you eat into the energy you need2.

Coenzyme A

Its main job is making coenzyme A (CoA), which moves acetyl and acyl groups in many reactions1.

Builds & breaks down fats

CoA is essential for both making and breaking down fatty acids1.

Acyl carrier protein

Also used to make acyl carrier protein, whose main role is building fatty acids1.

Hormones & cholesterol

Helps the body produce hormones and cholesterol3.

02 How your body uses it

How your body uses pantothenic acid.

How your body uses pantothenic acid: Food → Gut enzymes → Intestine → Red blood cells → Cells → At work. Gut bacteria add an unknown amount Intestine.01FoodMostly as CoA02Gut enzymesFree pantothenic acid03IntestineActive transport absorbs04Red blood cellsCarry it around the body05CellsBuild coenzyme A06At workFat and energy metabolismGut bacteriaMake some B5 tooadd an unknown amountHow your body uses pantothenic acid: Food → Gut enzymes → Intestine → Red blood cells → Cells → At work. Gut bacteria add an unknown amount Intestine.01FoodMostly as CoA02Gut enzymesFree pantothenic acid03IntestineActive transport absorbsGut bacteriaMake some B5too04Red blood cellsCarry it around the body05CellsBuild coenzyme A06At workFat and energy metabolism

About 85% of the pantothenic acid in food is CoA or phosphopantetheine, which digestive enzymes turn into free pantothenic acid before it is absorbed1. Red blood cells carry it through the body, and most of it in tissues is in the form of CoA1.

03 Where to get it

Foods and other sources.

Shiitake mushroomsSunflower seedsAvocadoChickenTunaMilkPotatoesEggsBroccoliWhole grains

Vegetarian

Food and servingAmount
Breakfast cereal, fortified with 100% of the DV5 mg
Shiitake mushrooms, cooked, ½ cup2.6 mg
Sunflower seeds, ¼ cup2.4 mg
Avocado, raw, ½1.0 mg
Milk, 2%, 1 cup0.9 mg
Potato, russet, baked, 1 medium0.7 mg
Broccoli, boiled, ½ cup0.5 mg

Non-vegetarian

Food and servingAmount
Beef liver, boiled, 3 oz8.3 mg
Chicken breast, skinless, roasted, 3 oz1.3 mg
Tuna, bluefin, cooked, 3 oz1.2 mg
Egg, hard boiled, 1 large0.7 mg
Ground beef, 85% lean, broiled, 3 oz0.6 mg

Almost all foods contain some pantothenic acid, but processing can remove 20% to almost 80% of it, and the body absorbs about half of what food provides1. Amounts per serving from1.

Fortified foods

Added to some breakfast cereals and to drinks such as energy drinks1.

Supplements

Sold alone, in B-complex products and in some multivitamin/mineral products1.

Gut bacteria

Intestinal bacteria make some pantothenic acid, but how much of it the body absorbs is not known1.

04 How much you need

Your daily reference amounts.

The same reference table draws the reference lines on your charts in Ayuvo. Needs differ in pregnancy and breastfeeding, which are not covered here.

Pantothenic acid: daily AI by age and sex
AgeWomenMen
19–305 mg5 mg
31–505 mg5 mg
51–705 mg5 mg
71+5 mg5 mg

AI (Adequate Intake) is used when there is not enough evidence for an RDA: an amount assumed to be enough. Per day, for adults1.

  • No upper limit is set because no toxicity from high intakes has been reported.
Pantothenic acid reference amounts for adults aged 31–50: AI 5 mgAI 5 mg0Adults 31–50, per day
Below the recommended amountMeets the reference
05 Balance

Too little, too much.

Signs like these have many possible causes. They are a reason to talk to a clinician, not to self-treat.

Too little

Deficiency is rare except in severe malnutrition, and it usually comes with other nutrient deficiencies1.

  • Numbness and burning of hands and feet
  • Headache
  • Fatigue
  • Irritability and restlessness
  • Disturbed sleep
  • Stomach upset and loss of appetite

Too much

No upper limit is set because no toxicity has been reported in humans, but very large supplement doses can upset the stomach1.

  • No known toxicity
  • Mild diarrhea at very high doses
  • Stomach discomfort
  • No known medicine interactions
06 Supplements

Supplement forms.

Pantothenic acid comes alone, in B-complex supplements and in some multivitamins, and no study has compared how well the different forms are absorbed1.

Calcium pantothenate

The most common form in supplements1.

Pantethine

Made of two pantetheine units; in small trials, large amounts were linked with lower blood lipids, which plain pantothenic acid does not appear to show1.

Which form?

Research has not shown that any form of pantothenic acid is better than the others2.

Supplements can interact with medicines. Talk to a clinician or pharmacist before you start one, especially at high doses.

07 Key points

Remember these five.

  1. Pantothenic acid is vitamin B5, the building block of coenzyme A.
  2. Almost every plant and animal food contains some.
  3. Food processing can strip out a large share of it.
  4. Deficiency is rare and usually appears alongside other nutrient shortfalls.
  5. No toxicity has been reported, though very large supplement doses can cause diarrhea.
FAQ

Questions about pantothenic acid.

Is pantothenic acid the same as vitamin B5?

Yes. Pantothenic acid is vitamin B5. In supplements it often appears as calcium pantothenate or pantethine, and in the body most of it becomes coenzyme A.

Can pantethine lower cholesterol?

Small trials found that large amounts of pantethine, a form of pantothenic acid, were linked with lower triglycerides and LDL cholesterol, but pantothenic acid itself does not seem to have the same effect. More research is needed, including on how it adds to a heart-healthy diet.

Can you get too much pantothenic acid?

No toxicity has been reported in humans, so no upper limit is set. Very large supplement doses, around 10 grams a day, have caused mild diarrhea and stomach upset.

Get started

Track pantothenic acid in Ayuvo.

Food logging does not estimate pantothenic acid, so Ayuvo tracks it from supplements you log in Medications, and from Apple Health on iPhone or Health Connect on Android when another app saves it there. Charts by day, week, month and year use the reference lines from this page, personalised by age and sex where they differ. Free, with no account.

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Or read the code: Ayuvo is open source

Sources

Facts on this page come from these sources, checked on the dates shown. Intake numbers come from Ayuvo's shared reference table, which cites the sources marked for them.

  1. Pantothenic Acid: Fact Sheet for Health Professionals · NIH Office of Dietary Supplements checked 2026-09-27
  2. Pantothenic Acid: Fact Sheet for Consumers · NIH Office of Dietary Supplements checked 2026-09-27
  3. Pantothenic acid and biotin: MedlinePlus Medical Encyclopedia · MedlinePlus, U.S. National Library of Medicine checked 2026-09-27

General information, not medical advice. This guide is for healthy adults and does not cover pregnancy, breastfeeding, children or medical conditions. It cannot diagnose or treat anything. Talk to a clinician before starting high-dose supplements, or if you think you may have too little or too much of a nutrient. Spotted an error? Email us.